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The function of SIK1 in tumorigenesis. SIK1 is really a tumor suppressor gene, which plays a crucial regulatory part in GNAS, KRAS mutation and LKB1 deletion mediated tumors. SIK1 inhibits CREB mediated transcription and impacts cancer cell proliferation, metabolic reprogramming and inflammatory microenvironment. SIK1 may also promote most cancers

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